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Open.Michigan is an online repository developed by the University of Michigan faculty of open access learning materials. There are lots of materials available, and many of the classes have an low-cost purchase option available of some materials for students who want a print copy of readings.
Most of the content on this site is published under CC BY license, which means you are free to use and adapt with attribution.
This site also has a wealth of online resources related to health and medicine
MIT's OpenCourseware site has many classes available to download and adapt via Creative Commons Licensing.
Many of the classes are complete with textbooks, syllabi, exam and quiz questions, and exercises, and some even include recorded lectures.
There are too many to list in this one box, but I've linked to specific areas to help you find what you need.
To download all course materials, make sure you visit the "Download Course Materials" link in the left side navigation.
Rice University founded OpenStax press in 2011 to create peer-reviewed, high-quality textbooks under a Creative Commons license. The textbooks also come with other class materials like homework ideas and study guides. They are releasing new subjects each semester, so the collection is slowly growing.
All of these textbooks can also be customized, or used as is.
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Open Course Library, created with grant funding by Washington State University, provides full courses paired with either free or open source textbooks that are all available via Creative Commons Licensing. Their handy How To Guide provides detailed instructions on how to access and download the class materiels.
For advanced uses, the courses can also be downloaded in Common Cartidge format (compatible with Blackboard) from their Connexions page.
College Open Textbooks is a clearing house site that lists open textbooks by subject. Not all of the textbooks listed have been "vetted" by the site editors, so you should review them carefully before using them in your classrooms.
Merlot offers a variety of learning materials: lesson plans, images, videos, syllubi, quizzes and exams, and even textbooks. Items contributed to the Merlot site are peer reviewed by an editorial board.
While you can search all of Merlot, here are some collections that serve as portals to discipline specific materials.
PubMed Central is "...a free archive of biomedical and life sciences journal literature at the U.S. National Institutes of Health's National Library of Medicine (NIH/NLM). In keeping with NLM’s legislative mandate to collect and preserve the biomedical literature, PMC serves as a digital counterpart to NLM’s extensive print journal collection. Launched in February 2000, PMC was developed and is managed by NLM’s National Center for Biotechnology Information (NCBI)."
Currently, it contains over 3.2 million articles.